Lutz Frölich Selected Research

(2- (6- fluoro- 1H- indol- 3- yl)- ethyl)- (3- (2,2,3,3- tetrafluoropropoxy)benzyl)amine

1/2019	Open-Label, Multicenter, Phase III Extension Study of Idalopirdine as Adjunctive to Donepezil for the Treatment of Mild-Moderate Alzheimer's Disease.
1/2018	Effect of Idalopirdine as Adjunct to Cholinesterase Inhibitors on Change in Cognition in Patients With Alzheimer Disease: Three Randomized Clinical Trials.

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Lutz Frölich Research Topics

Disease

80	Alzheimer Disease (Alzheimer's Disease) 06/2022 - 01/2003
43	Dementia (Dementias) 01/2022 - 01/2004
40	Cognitive Dysfunction 01/2022 - 11/2008
7	Disease Progression 01/2022 - 01/2004
4	Atrophy 02/2015 - 07/2003
3	Inflammation (Inflammations) 01/2022 - 12/2011
3	Prodromal Symptoms 07/2021 - 12/2011
3	Neurodegenerative Diseases (Neurodegenerative Disease) 01/2017 - 01/2009
2	Delirium 01/2020 - 03/2011
2	Vascular Dementia (Subcortical Arteriosclerotic Encephalopathy) 01/2019 - 07/2003
2	Insulin Resistance 04/2015 - 04/2015
2	Atrial Fibrillation 12/2014 - 05/2014
1	Pneumonia (Pneumonitis) 01/2021
1	Hypoxia (Hypoxemia) 01/2021
1	COVID-19 01/2021
1	Confusion (Bewilderment) 01/2021
1	Amyloid Plaque 12/2020
1	Clinical Deterioration 01/2020
1	Arachnoid Cysts (Intracranial Arachnoid Cysts) 01/2019
1	Lewy Body Disease (Lewy Body Dementia) 01/2019
1	Parkinson Disease (Parkinson's Disease) 01/2017
1	Multiple Sclerosis 01/2017
1	Headache (Headaches) 02/2016
1	Back Pain (Backache) 02/2016
1	Genetic Risk Score 01/2016
1	Amyloidosis 02/2015
1	Bipolar Disorder (Manic Depressive Psychosis) 06/2009

Drug/Important Bio-Agent (IBA)

40	Biomarkers (Surrogate Marker)IBA 01/2022 - 11/2003
21	Amyloid (Amyloid Fibrils)IBA 01/2022 - 01/2003
11	Proteins (Proteins, Gene)FDA Link 01/2022 - 01/2003
8	Apolipoproteins E (ApoE)IBA 01/2020 - 01/2013
7	Amyloid beta-PeptidesIBA 01/2022 - 05/2007
6	Cholinesterase Inhibitors (Anticholinesterases)IBA 01/2019 - 01/2004
6	Pharmaceutical PreparationsIBA 01/2016 - 06/2009
5	ApolipoproteinsIBA 01/2020 - 01/2015
4	tau Proteins (tau Protein)IBA 12/2020 - 01/2009
4	Rivastigmine (Exelon)FDA LinkGeneric 01/2015 - 04/2009
3	Blood Proteins (Serum Proteins)IBA 01/2021 - 11/2019
3	Peptides (Polypeptides)IBA 12/2020 - 05/2007
3	LipidsIBA 09/2019 - 12/2011
3	Donepezil (Aricept)FDA LinkGeneric 01/2019 - 01/2003
3	Insulin (Novolin)FDA Link 04/2015 - 01/2006
2	Apolipoprotein E4IBA 01/2022 - 06/2010
2	Psychotropic Drugs (Psychoactive Drugs)IBA 01/2021 - 01/2010
2	Antipsychotic Agents (Antipsychotics)IBA 01/2020 - 01/2014
2	Amino Acids FDA Link 01/2020 - 05/2007
2	Norepinephrine (Noradrenaline)FDA LinkGeneric 01/2020 - 01/2006
2	Complement System Proteins (Complement)IBA 01/2020 - 01/2019
2	Memantine (Namenda)FDA Link 01/2019 - 11/2015
2	(2- (6- fluoro- 1H- indol- 3- yl)- ethyl)- (3- (2,2,3,3- tetrafluoropropoxy)benzyl)amineIBA 01/2019 - 01/2018
2	Galantamine (Galanthamine)FDA LinkGeneric 11/2015 - 01/2009
2	Biological ProductsIBA 03/2015 - 02/2011
2	Presenilin-1IBA 03/2014 - 01/2003
1	Dithionitrobenzoic Acid (Ellman's Reagent)IBA 01/2022
1	Matrix Metalloproteinase 10 (Stromelysin 2)IBA 01/2022
1	Anti-Infective Agents (Microbicides)IBA 12/2020
1	Phospholipids (Phosphatides)FDA LinkGeneric 10/2020
1	LysophospholipidsIBA 10/2020
1	Intrinsically Disordered ProteinsIBA 01/2020
1	Anti-Anxiety Agents (Anxiolytics)IBA 01/2020
1	Tryptophan (L-Tryptophan)FDA Link 01/2020
1	Dopamine (Intropin)FDA LinkGeneric 01/2020
1	EnzymesIBA 01/2020
1	Glycine (Aminoacetic Acid)FDA LinkGeneric 01/2020
1	Bupropion (Wellbutrin)FDA LinkGeneric 01/2020
1	Hypnotics and Sedatives (Sedatives)IBA 01/2020
1	Phosphoric Diester Hydrolases (Phosphodiesterases)IBA 12/2019
1	BI 409306IBA 12/2019
1	Nimodipine (Modus)FDA LinkGeneric 01/2019
1	AmidesIBA 01/2019
1	Carrier Proteins (Binding Protein)IBA 01/2019
1	TabletsIBA 01/2019
1	N-Methyl-D-Aspartate Receptors (NMDA Receptors)IBA 01/2019
1	Hydrocortisone (Cortisol)FDA LinkGeneric 02/2015
1	Pemetrexed (MTA)FDA Link 02/2015
1	AnticoagulantsIBA 12/2014
1	Dabigatran FDA Link 05/2014
1	RivaroxabanIBA 05/2014
1	apixabanIBA 05/2014
1	Presenilin-2IBA 03/2014
1	OrexinsIBA 02/2014
1	Protein Isoforms (Isoforms)IBA 01/2013
1	Biocompatible Materials (Biomaterials)IBA 01/2011
1	isproniclineIBA 01/2011
1	N-acetylaspartate (N-acetyl aspartate)IBA 01/2011
1	CholesterolIBA 11/2010
1	phenserineIBA 01/2010
1	CreatineIBA 07/2009
1	LithiumIBA 06/2009
1	Glycogen Synthase (Synthase I)IBA 06/2009
1	Phosphotransferases (Kinase)IBA 06/2009

Therapy/Procedure

10	Therapeutics 06/2022 - 01/2004
9	Activities of Daily Living (ADL) 01/2020 - 12/2011
2	Drug Therapy (Chemotherapy) 01/2019 - 01/2014
1	Home Nursing (Nursing, Home) 01/2021
1	Critical Care (Surgical Intensive Care) 01/2021
1	Length of Stay 01/2020
1	Secondary Prevention 11/2019
1	Punctures 02/2016
1	Cognitive Training 07/2012